Wentz threw for 291 yards and four touchdowns before limping off in the third quarter as the Eagles held on to claim a pulsating 43-35 victory at the Los Angeles Memorial Coliseum.
But the gloss was taken off the win after Wentz's injury.
ESPN reported Sunday that the Eagles star had suffered a season-ending torn knee ligament, dealing a massive blow to a team who had been many pundits' favorites for the Super Bowl.
The win saw the Eagles improve to 11-2 at the top of the NFC East, guaranteeing them their first divisional title since 2013.
The Rams meanwhile remain on top of the NFC West at 9-5, one game ahead of the Seattle Seahawks (8-5) who fell 30-24 to the Jacksonville Jaguars on Sunday.
The Eagles victory came after a gutsy fourth quarter fightback when they clawed back the momentum as the Rams appeared to be closing in on victory.
Wentz had earlier steered the Eagles to a 21-7 lead early in the second quarter to leave the hosts in trouble.
However the Rams hit back with touchdowns from Cooper Kupp and Sammy Watkins before a blocked Eagles punt allowed Blake Countess to score a touchdown to put them 28-24 up.
Wentz bravely regained his composure after suffering a heavy hit to find Alshon Jeffery with a two-yard touchdown pass to make it 31-28.
But the Eagles signal-caller then left the game with a left knee injury and was receiving treatment when Rams running back Todd Gurley rushed for his second touchdown of the day to make it 35-31.
The Eagles cut the Rams lead to one-point with a Jake Elliott field goal.
Crucially, Rams quarterback Jared Goff then fumbled to hand back possession to the Eagles, and Elliott subsequently kicked the go-ahead field goal.
With the final play of the game, Brandon Graham recovered a Rams fumble to complete the Eagles win.
- Dallas spoil Manning return -
Elsewhere Sunday, the Dallas Cowboys stayed alive in their quest for a wildcard berth with a 30-10 win over the New York Giants.
Dallas quarterback Dak Prescott finished with a career-high 332 yards as Dallas improved to 7-6 in the NFC East to stay in the postseason chase.
But it was a miserable return to the starting line-up for Prescott's Giants counterpart Eli Manning, who was cheered by fans but ultimately disappointed in his first start since he was benched last week.
Manning and the Giants were blown away by three fourth quarter Dallas touchdowns from Jason Witten and Rod Smith (2).
Dallas will realistically need to win their three remaining games against Oakland, Seattle and Philadelphia to have any chance of snatching a wildcard spot.
In other games Sunday, the Carolina Panthers jolted the Minnesota Vikings 34-21 after a three-touchdown rushing display from Jonathan Stewart.
Stewart grabbed the first of his three scores with a 60-yard gallop to the end zone in the first quarter as the Panthers boosted their playoff hopes to improve to 9-4. The Vikings slipped to 10-3 but remain atop the NFC North.
In Cleveland, the Browns looked poised to score their first victory of the season after leading 21-7 against the Green Bay Packers in the fourth quarter.
But two Packers touchdowns from Jamaal Williams and Davante Adams sent the game into overtime where Adams scored again to seal a 27-21 win.
In Buffalo, the Bills overcame blizzard-like conditions to beat the Indianapolis Colts 13-17 in overtime in a game played with thick snow blanketing the pitch.
"It was crazy," Colts quarterback Jacoby Brissett said of the conditions.
"I never played in this in my life or played in the snow. Every time it snowed, I was in the house. It was definitely a different experience."
source: news.abs-cbn.com
