It was the first road loss by the Spurs, who played behind most of the game before closing the gap in the fourth quarter and faltering.
Jimmy Butler added 13 points and nine rebounds for Chicago (12-10), which saw all its starters score in double digits.
Kawhi Leonard led San Antonio (18-5) with 24 points. The Spurs entered the game with a 13-0 record on the road.
In Toronto, DeMar DeRozan scored 27 points and Kyle Lowry tallied 25 points and 11 assists as the Toronto Raptors rallied to beat the Minnesota Timberwolves 124-110 in Andrew Wiggins' homecoming game.
Wiggins scored 11 of his 25 points in the first quarter but the Timberwolves were no match for the offensive firepower of the Raptors (14-7) at home.
Wiggins, who was the first overall draft pick in 2014, is from the Toronto area and receives plenty of attention each time he crosses the border to play.
Zach LaVine scored 29 points and Karl-Anthony Towns recorded 17 points and 11 rebounds for Minnesota (6-16).
In Salt Lake City, the Golden State Warriors raced out to a massive lead but needed to quell a second-half rally by the Utah Jazz to win 106-99.
It was 29-5 at one point for the Warriors (20-3), but the Jazz clawed their way back into the game, coming as close as 84-79 in the fourth quarter.
Kevin Durant scored eight straight points to grow the Warriors' lead back to double digits and secure the win.
Steph Curry scored 26 points, while Durant added 21 points and 11 rebounds.
Rudy Gobert finished with 20 points and 17 rebounds for Utah (14-10), which were without four starters dealing with injuries.
In other games, Washington beat Denver 92-85, Memphis defeated Portland 88-86 and Philadelphia downed New Orleans 99-88.
source: news.abs-cbn.com
