Showing posts with label Clinical Trial. Show all posts
Showing posts with label Clinical Trial. Show all posts

Wednesday, March 9, 2016

First US uterus transplant fails


The first uterus transplant to be performed in the United States failed after the recipient suffered complications that prompted doctors to remove the organ, the Cleveland Clinic said on Wednesday.

"We are saddened to share that our patient, Lindsey, recently experienced a sudden complication that led to the removal of her transplanted uterus," the hospital said in a statement that did not give the patient's last name.

She was "doing well" and "recovering" after surgery to remove the organ, it added without elaborating.

The transplant, which lasted nine hours, took place on February 25. Doctors announced several days later that the operation had been a success.

On Monday, the surgical team held a news conference during which the 26-year-old recipient briefly appeared smiling.

The hospital said it is reviewing why the transplant failed, adding that its clinical trial -- which aims to carry out uterus transplants in 10 women -- will continue.

Doctors at Sweden's University of Gothenburg were the first to successfully perform a uterus transplant in 2013.

The recipient gave birth to the first child to be conceived in an implanted womb in September 2014.

The Swedish team has enabled four healthy births to date.

The transplant is temporary, meant to enable women to deliver up to two children over a five-year period.

The transplanted uterus must then be removed to end exposure to drugs meant to prevent women's bodies from rejecting the transplanted organs.

source: www.abs-cbnnews.com

Wednesday, February 15, 2012

Want to lose weight? Trade sugary drinks for water


NEW YORK -- Swapping your soda for water -- or at least diet soda -- really can help you shed a few pounds, a new clinical trial finds.

A common piece of advice in the battle of the bulge is to replace sugar-sweetened drinks with water or other calorie-free thirst quenchers.

But while that advice is logical, there hasn't been research to show whether changing your drinking habits alone actually works.

So for the new study, researchers randomly assigned 318 overweight adults to one of three groups: one that replaced sugary drinks with water; one that substituted with diet beverages; and one that was given weight-loss advice and could make diet changes of their choice.

After six months, all three groups lost four or five pounds, on average.

But the two groups that cut sugary drinks were more likely to shed at least five percent of their starting weight: 20 percent did, versus 11 percent of the comparison group.

A five-percent weight loss is considered "clinically meaningful" -- or enough to see health benefits like a drop in blood pressure, said lead researcher Deborah F. Tate, of the University of North Carolina at Chapel Hill.

People who need to lose weight often find a diet overhaul too daunting. But swapping a couple sweet drinks for sugar-free alternatives may seem relatively easy, according to Tate.

"This is a simple thing you can do consistently each day," she said in an interview.

On average, people in this study lost around two percent of their body weight. That's not huge, but it's a move in the right direction, the researchers say.

"It might be a good first step," Tate said. After getting used to calorie-free drinks, she said, you can add changes to your eating habits.

The findings, reported in the American Journal of Clinical Nutrition, are based on adults who were significantly obese, on average, and were downing at least 280 liquid calories each day (excluding milk).

The two beverage groups were told to replace two of those daily drinks with water or diet beverages. The third group was given general weight-loss information, but could make their own diet decisions. All three groups had monthly meetings and access to a group website.

After six months, all three groups had a similar average weight loss.

The water group, however, shaved several points off their blood sugar and blood pressure levels -- more than the diet beverage group.

It's not clear why that is, Tate said. But the water group had better hydration levels, which might help explain the improved blood pressure.

"For other health reasons, water might be better" than diet drinks, Tate said. She added, though, that diet versions of people's favorite drinks might be easier to stick with for the long haul.

Some past studies have found that people who regularly drink diet soda actually have a higher diabetes risk than folks who steer clear of artificially-sweetened drinks.

But the reasons for that connection are unknown, and it might not be anything about diet drinks per se.

Tate said that longer-term follow-up of the people in this study will offer a way to look at that question. By and large, participants had not been drinking diet beverages before the study; so the researchers can look at whether switching to diet has any negative effects on blood sugar or other health markers.

The study was funded by Nestle Waters USA.

source: interaksyon.com