The blue-chip index smashed above the milestone at the open and stayed in positive territory the entire session, finishing at 22,016.24.
Apple was the biggest gainer in the index, rising 4.7 percent after reporting better-than-expected earnings Tuesday and emphasizing its increased sales of digital content and services.
US stocks have risen to a succession of records over the last couple of weeks as second-quarter earnings have broadly bested expectations.
Some observers say stocks could find it hard to score additional gains given the already-lofty valuations, but others still see more potential upside.
"What's going on is good earnings and at the end of the day, earnings drives the markets," said JJ Kinahan, chief market strategist at TD Ameritrade. "It's been a pretty amazing season."
But equity markets elsewhere were mixed, with disappointing earnings at banking giants Societe Generale and Commerzbank weighing on Paris and Frankfurt, respectively.
London also pulled back ahead of Thursday's Bank of England decision.
DOLLAR IN RETREAT
European bourses also were pressured by the rising value of the single currency against the dollar. The euro moved above $1.19 for the first time since January 2015 before retreating somewhat.
"Investors continued to shun the (dollar) amid a backdrop of mounting dysfunction in Washington and mixed US economic data that have done little to encourage bets that the Fed will raise lending rates again this year," said Omer Esiner, analyst at Commonwealth FX.
Kinahan said the sinking dollar was a potential hindrance to future US stock gains.
A move by the euro above $1.20 would "cause significantly more worry," Kinahan said, because it would signal a loss of faith that the Federal Reserve will continue raising interest rates.
That would suggest "that the economy is starting to slow down," he added.
A trigger for further losses in the greenback could come as soon as Friday if the US jobs report for July disappoints and is seen lessening the odds of additional Fed rate hikes.
KEY FIGURES AROUND 2100 GMT (5 a.m. in Manila)
New York - Dow: UP 0.2 percent at 22,016.24 (close)
New York - S&P 500: UP 0.1 percent at 2,477.57 (close)
New York - Nasdaq: DOWN less than 0.1 percent at 6,362.65 (close)
London - FTSE 100: DOWN 0.2 percent at 7,411.43 points (close)
Frankfurt - DAX 30: DOWN 0.6 percent at 12,181.48 (close)
Paris - CAC 40: DOWN 0.4 percent at 5,107.25 (close)
EURO STOXX 50: DOWN 0.5 percent at 3,459.32
Tokyo - Nikkei 225: UP 0.5 percent at 20,080.04 (close)
Hong Kong - Hang Seng: UP 0.2 percent at 27,607.38 (close)
Shanghai - Composite: DOWN 0.2 percent at 3,285.06 (close)
Euro/dollar: UP at $1.1855 from $1.1801 at 2100 GMT on Tuesday
Pound/dollar: UP at $1.3225 from $1.3206
Dollar/yen: UP at 110.72 yen from 110.36 yen
Oil - Brent North Sea: UP 58 cents at $52.36 per barrel
Oil - West Texas Intermediate: UP 43 cents at $49.59 per barrel
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source: news.abs-cbn.com
